大阪大学大学院医学系研究科　腎疾患臓器連関制御学 (Department of Inter-Organ Communication Research in Kidney Disease, Osaka University Graduate School of Medicine)

当講座へ興味をお持ちの方へ

☆臨床医の方へ

臨床的な研究をしたい、きっちりとした生物統計学・疫学を大学院で学びたいという臨床医の方はご相談ください。喜んで対応させて頂きます。出身大学は問いません。

☆企業の方へ

本講座は、中外製薬株式会社、大塚製薬株式会社、テルモ株式会社、キッセイ薬品工業株式会社、扶桑薬品工業株式会社、医療法人好輝会梶本クリニック、医療法人紀陽会田仲北野田病院、社会医療法人三上会東香里病院、医療法人淳康会堺近森病院、社会医療法人純幸会関西メディカル病院、貴生病院、医療法人徳靖会小尾クリニックからの奨学寄付金を頂いております。また、上記以外の複数の企業と共同研究を行っております。当講座との共同研究にご興味のある方はご連絡ください。

研究内容

ミネラル骨代謝異常(CKD-MBD)、腎性貧血、遺伝性腎疾患を中心とした慢性腎臓病(CKD)に関する研究を行っています。

現在当講座が携わっている臨床研究

当講座が携わり、大阪大学医学部附属病院 腎臓内科などにおいて実施されている臨床研究に関する情報を公開しています。お問い合わせは各臨床研究の事務局までお願いします。

Epoetin Beta Pegolによる移植後貧血の正常化と天然型ビタミンD3の補充が移植腎機能に及ぼす影響を検討するランダム化比較試験：CANDLE-KIT Trial

「保存期慢性腎臓病患者の心血管合併症に対するクレメジン®/マグラックス®投与の有用性評価」研究

『 コレカルシフェロールの投与が 血液透析患者の腎性貧血および骨代謝に 及ぼす影響を検討するプラセボ対照・二重盲検・ランダム化比較試験』

　　　　　

「透析療法中の骨粗鬆症におけるテリボン®投与の薬物動態と安全性の検討」研究

　　　　　

『 高リン血症を呈する保存期慢性腎臓病患者の血管障害に対する影響を検討する炭酸ランタンと炭酸カルシウムのランダム化比較試験 』

　　　　　

慢性腎臓病合併浮腫患者のコホート研究


under construction

　　　

これまでに当講座が関わった研究業績

2019年

1. VEGF-A Links Angiolymphoid Hyperplasia With Eosinophilia (ALHE) to THSD7A Membranous Nephropathy: A Report of 2 Cases.

   Matsumoto A, Matsui I, Namba T, Sakaguchi Y, Mizuno H, Shirayama Y, Shimada K, Hashimoto N, Doi Y, Yamaguchi S, Kubota K, Oka T, Mori D, Akiyama S, Hamano T, Mizui M, Takabatake Y, Kaneko T, Isaka Y.

   Am J Kidney Dis. 2019 Jun;73(6):880-885. doi: 10.1053/j.ajkd.2018.10.009. Epub 2018 Dec 13.

2. The association of the difference in hemoglobin levels before and after hemodialysis with the risk of 1-year mortality in patients undergoing hemodialysis. Results from a nationwide cohort study of the Japanese Renal Data Registry.

   Nishiwaki H, Hasegawa T, Koiwa F, Hamano T, Masakane I.

   PLoS One. 2019 Jan 10;14(1):e0210533. doi: 10.1371/journal.pone.0210533. eCollection 2019.
   
3. Adiposity and risk of decline in glomerular filtration rate: meta-analysis of individual participant data in a global consortium.

   Chang AR, Grams ME, Ballew SH, Bilo H, Correa A, Evans M, Gutierrez OM, Hosseinpanah F, Iseki K, Kenealy T, Klein B, Kronenberg F, Lee BJ, Li Y, Miura K, Navaneethan SD, Roderick PJ, Valdivielso JM, Visseren FLJ, Zhang L, Gansevoort RT, Hallan SI, Levey AS, Matsushita K, Shalev V, Woodward M; CKD Prognosis Consortium (CKD-PC).

   BMJ. 2019 Jan 10;364:k5301. doi: 10.1136/bmj.k5301.

4. Parathyroid hormone and premature thymus ageing in patients with chronic kidney disease.

   Iio K, Kabata D, Iio R, Imai Y, Hatanaka M, Omori H, Hoshida Y, Saeki Y, Shintani A, Hamano T, Isaka Y, Ando Y.

   Sci Rep. 2019 Jan 28;9(1):813. doi: 10.1038/s41598-018-37511-9.

5. Predilution online hemodiafiltration is associated with improved survival compared with hemodialysis.

   Kikuchi K, Hamano T, Wada A, Nakai S, Masakane I.

   Kidney Int. 2019 Apr;95(4):929-938. doi: 10.1016/j.kint.2018.10.036. Epub 2019 Feb 16.

6. Transient Cornea Verticillata of Unknown Etiology: A Case Report.

   Koh S, Hamano T, Ichii M, Yatsui K, Maeda N, Nishida K.

   Cornea. 2019 May;38(5):e16-e17. doi: 10.1097/ICO.0000000000001913. No abstract available.

7. Glycemic control and survival in peritoneal dialysis patients with diabetes: A 2-year nationwide cohort study.

   Abe M, Hamano T, Hoshino J, Wada A, Nakai S, Masakane I.

   Sci Rep. 2019 Mar 1;9(1):3320. doi: 10.1038/s41598-019-39933-5.

8. Predictors of outcomes in patients on peritoneal dialysis: A 2-year nationwide cohort study.

   Abe M, Hamano T, Hoshino J, Wada A, Nakai S, Hanafusa N, Masakane I, Nitta K, Nakamoto H.

   Sci Rep. 2019 Mar 8;9(1):3967. doi: 10.1038/s41598-019-40692-6.
   

9. Hemodialysis Product and Hip Fracture in Hemodialysis Patients: A Nationwide Cohort Study in Japan.

   Wakasugi M, Kazama JJ, Kikuchi K, Yasuda K, Wada A, Hamano T, Masakane I, Narita I.

   Ther Apher Dial. 2019 Apr 2. doi: 10.1111/1744-9987.12807. [Epub ahead of print]

10. Dialysis initiation, modality choice, access, and prescription: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.

    Chan CT, Blankestijn PJ, Dember LM, Gallieni M, Harris DCH, Lok CE, Mehrotra R, Stevens PE, Wang AY, Cheung M, Wheeler DC, Winkelmayer WC, Pollock CA; Conference Participants.

    Kidney Int. 2019 Jul;96(1):37-47. doi: 10.1016/j.kint.2019.01.017. Epub 2019 Apr 13.

11. Types of Erythropoietin-Stimulating Agents and Mortality among Patients Undergoing Hemodialysis.

    Sakaguchi Y, Hamano T, Wada A, Masakane I.

    J Am Soc Nephrol. 2019 Jun;30(6):1037-1048. doi: 10.1681/ASN.2018101007. Epub 2019 Apr 23.

12. A Randomized Trial of Magnesium Oxide and Oral Carbon Adsorbent for Coronary Artery Calcification in Predialysis CKD.

    日本語解説
    Sakaguchi Y, Hamano T, Obi Y, Monden C, Oka T, Yamaguchi S, Matsui I, Hashimoto N, Matsumoto A, Shimada K, Takabatake Y, Takahashi A, Kaimori JY, Moriyama T, Yamamoto R, Horio M, Yamamoto K, Sugimoto K, Rakugi H, Isaka Y.

    J Am Soc Nephrol. 2019 Jun;30(6):1073-1085. doi: 10.1681/ASN.2018111150. Epub 2019 Apr 29.

13. Renal involvement in the pathogenesis of mineral and bone disorder in dystrophin-deficient mdx mouse.

    Wada E, Hamano T, Matsui I, Yoshida M, Hayashi YK, Matsuda R.

    J Physiol Sci. 2019 Jul;69(4):661-671. doi: 10.1007/s12576-019-00683-8. Epub 2019 May 11.

14. Quantitative evaluation of visual function in patients with cornea verticillata associated with Fabry disease.

    Koh S, Haruna M, Asonuma S, Maeda N, Hamano T, Sakai N, Hara C, Maruyama K, Nishida K.

    Acta Ophthalmol. 2019 May 24. doi: 10.1111/aos.14143. [Epub ahead of print]

15. Hyperphosphatemia is not significantly associated with increased all-cause mortality in Korean hemodialysis patients.

    Wakasugi M, Sakaguchi Y.

    Kidney Res Clin Pract. 2018 Dec;37(4):420-421. doi: 10.23876/j.krcp.18.0129. Epub 2018 Dec 31. No abstract available.

16. under construction

2018年

1. Glycated albumin versus hemoglobin A1c and mortality in diabetic hemodialysis patients: a cohort study.

   Hoshino J, Hamano T, Abe M, Hasegawa T, Wada A, Ubara Y, Takaichi K, Inaba M, Nakai S, Masakane I; Committee of Renal Data Registry of the Japanese Society for Dialysis Therapy.

   Nephrol Dial Transplant. 2018 Jul 1;33(7):1150-1158. doi: 10.1093/ndt/gfy014.

2. Hip Fracture Trends in Japanese Dialysis Patients, 2008-2013.

   Wakasugi M, Kazama JJ, Wada A, Hamano T, Masakane I, Narita I.

   Am J Kidney Dis. 2018 Feb;71(2):173-181. doi: 10.1053/j.ajkd.2017.07.017. Epub 2017 Nov 20.
   
3. Association of Pre-ESRD Serum Calcium With Post-ESRD Mortality Among Incident ESRD Patients: A Cohort Study.

   Obi Y, Park C, Soohoo M, Sumida K, Hamano T, Rhee CM, Kovesdy CP, Kalantar-Zadeh K, Streja E.

   J Bone Miner Res. 2018 Jun;33(6):1027-1036. doi: 10.1002/jbmr.3391. Epub 2018 Mar 23.

4. Rationale, design, and characteristics of a trial to evaluate the new phosphate iron-based binder sucroferric oxyhydroxide in dialysis patients with the goal of advancing the practice of E.B.M. (EPISODE).

   Isaka Y, Fujii H, Tsujimoto Y, Teramukai S, Hamano T.

   Clin Exp Nephrol. 2018 Aug;22(4):967-972. doi: 10.1007/s10157-018-1547-5. Epub 2018 Mar 13.

5. Protein carbamylation exacerbates vascular calcification.

   日本語解説
   Mori D, Matsui I, Shimomura A, Hashimoto N, Matsumoto A, Shimada K, Yamaguchi S, Oka T, Kubota K, Yonemoto S, Sakaguchi Y, Takahashi A, Shintani Y, Takashima S, Takabatake Y, Hamano T, Isaka Y

   Kidney Int. 2018 Jul;94(1):72-90. doi: 10.1016/j.kint.2018.01.033. Epub 2018 Apr 30.

6. Cardiac hypertrophy elevates serum levels of fibroblast growth factor 23.

   日本語解説
   Matsui I, Oka T, Kusunoki Y, Mori D, Hashimoto N, Matsumoto A, Shimada K, Yamaguchi S, Kubota K, Yonemoto S, Higo T, Sakaguchi Y, Takabatake Y, Hamano T, Isaka Y.

   Kidney Int. 2018 Jul;94(1):60-71. doi: 10.1016/j.kint.2018.02.018. Epub 2018 May 8

7. Vitamin D and Calcimimetics in Cardiovascular Disease.

   Lim K, Hamano T, Thadhani R.

   Semin Nephrol. 2018 May;38(3):251-266. doi: 10.1016/j.semnephrol.2018.02.005. Review.

8. Magnesium and Progression of Chronic Kidney Disease: Benefits Beyond Cardiovascular Protection?

   Sakaguchi Y, Hamano T, Isaka Y.

   Adv Chronic Kidney Dis. 2018 May;25(3):274-280. doi: 10.1053/j.ackd.2017.11.001. Review.
   

9. Proteinuria-associated renal magnesium wasting leads to hypomagnesemia: a common electrolyte abnormality in chronic kidney disease.

   日本語解説
   Oka T, Hamano T, Sakaguchi Y, Yamaguchi S, Kubota K, Senda M, Yonemoto S, Shimada K, Matsumoto A, Hashimoto N, Mori D, Monden C, Takahashi A, Obi Y, Yamamoto R, Takabatake Y, Kaimori JY, Moriyama T, Horio M, Matsui I, Isaka Y.

   Nephrol Dial Transplant. 2018 May 22. doi: 10.1093/ndt/gfy119. [Epub ahead of print]

10. Red cell distribution width and renal outcome in patients with non-dialysis-dependent chronic kidney disease.

    Yonemoto S, Hamano T, Fujii N, Shimada K, Yamaguchi S, Matsumoto A, Kubota K, Hashimoto N, Oka T, Senda M, Sakaguchi Y, Matsui I, Isaka Y.

    PLoS One. 2018 Jun 11;13(6):e0198825. doi: 10.1371/journal.pone.0198825. eCollection 2018.

11. Mineral and bone disorders in conventional hemodialysis: Challenges and solutions.

    Hamano T.

    Semin Dial. 2018 Nov;31(6):592-598. doi: 10.1111/sdi.12729. Epub 2018 Jun 13.

12. Higher dialysate calcium concentration is associated with incident myocardial infarction among diabetic patients with low bone turnover: a longitudinal study.

    Tagawa M, Hamano T, Sueta S, Ogata S, Saito Y.

    Sci Rep. 2018 Jul 3;8(1):10060. doi: 10.1038/s41598-018-28422-w.
    

13. Magnesium in Hemodialysis Patients: A New Understanding of the Old Problem.

    Sakaguchi Y, Hamano T, Isaka Y.

    Contrib Nephrol. 2018;196:58-63. doi: 10.1159/000485700. Epub 2018 Jul 24.

14. Low magnesium diet aggravates phosphate-induced kidney injury.

    Sakaguchi Y, Hamano T, Matsui I, Oka T, Yamaguchi S, Kubota K, Shimada K, Matsumoto A, Hashimoto N, Isaka Y.

    Nephrol Dial Transplant. 2018 Dec 7. doi: 10.1093/ndt/gfy358. [Epub ahead of print]

15. Relationship of Estimated GFR and Albuminuria to Concurrent Laboratory Abnormalities: An Individual Participant Data Meta-analysis in a Global Consortium.

    Inker LA, Grams ME, Levey AS, Coresh J, Cirillo M, Collins JF, Gansevoort RT, Gutierrez OM, Hamano T, Heine GH, Ishikawa S, Jee SH, Kronenberg F, Landray MJ, Miura K, Nadkarni GN, Peralta CA, Rothenbacher D, Schaeffner E, Sedaghat S, Shlipak MG, Zhang L, van Zuilen AD, Hallan SI, Kovesdy CP, Woodward M, Levin A; CKD Prognosis Consortium.

    Am J Kidney Dis. 2018 Oct 19. pii: S0272-6386(18)30916-8. doi: 10.1053/j.ajkd.2018.08.013. [Epub ahead of print]

16. Prognostic value of hypochloremia versus hyponatremia among patients with chronic kidney disease-a retrospective cohort study.

    日本語解説
    Kubota K, Sakaguchi Y, Hamano T, Oka T, Yamaguchi S, Shimada K, Matsumoto A, Hashimoto N, Mori D, Matsui I, Isaka Y.

    Nephrol Dial Transplant. 2018 Oct 20. doi: 10.1093/ndt/gfy299. [Epub ahead of print]

17. A Case of Severe Osteomalacia with Dent Disease Caused by a Novel Intronic Mutation of the CLCN5 gene.

    日本語解説
    Matsumoto A, Matsui I, Mori T, Sakaguchi Y, Mizui M, Ueda Y, Takahashi A, Doi Y, Shimada K, Yamaguchi S, Kubota K, Hashimoto N, Oka T, Takabatake Y, Sohara E, Hamano T, Uchida S, Isaka Y.

    Intern Med. 2018 Aug 10. doi: 10.2169/internalmedicine.1272-18. [Epub ahead of print]

2017年

1. Vitamin D and renal outcome: the fourth outcome of CKD-MBD? Oshima Award Address 2015.

   Hamano T.

   Clin Exp Nephrol. 2018 Apr;22(2):249-256. doi: 10.1007/s10157-017-1517-3. Epub 2017 Dec 21. Review.

2. Effects of Magnesium on the Phosphate Toxicity in Chronic Kidney Disease: Time for Intervention Studies.

   Sakaguchi Y, Hamano T, Isaka Y.

   Nutrients. 2017 Feb 6;9(2). pii: E112. doi: 10.3390/nu9020112. Review.

3. Anion Gap as a Determinant of Ionized Fraction of Divalent Cations in Hemodialysis Patients.

   日本語解説
   Sakaguchi Y, Hamano T, Kubota K, Oka T, Yamaguchi S, Matsumoto A, Hashimoto N, Mori D, Obi Y, Matsui I, Isaka Y.

   Clin J Am Soc Nephrol. 2018 Feb 7;13(2):274-281. doi: 10.2215/CJN.07930717. Epub 2017 Nov 27.

4. Magnesium and Risk of Hip Fracture among Patients Undergoing Hemodialysis.

   Sakaguchi Y, Hamano T, Wada A, Hoshino J, Masakane I.

   J Am Soc Nephrol. 2018 Mar;29(3):991-999. doi: 10.1681/ASN.2017080849. Epub 2017 Nov 30.

5. Lymphocyte Cell Ratios and Mortality among Incident Hemodialysis Patients.

   Catabay C, Obi Y, Streja E, Soohoo M, Park C, Rhee CM, Kovesdy CP, Hamano T, Kalantar-Zadeh K.

   Am J Nephrol. 2017;46(5):408-416. doi: 10.1159/000484177. Epub 2017 Nov 7.

6. In response to 'benefits and risks of intensive blood-pressure lowering in advanced chronic kidney disease'.

   Obi Y, Kalantar-Zadeh K, Shintani A, Kovesdy CP, Hamano T.

   J Intern Med. 2018 Jun;283(6):607-610. doi: 10.1111/joim.12734. Epub 2018 Mar 12

7. Estimated glomerular filtration rate and the risk-benefit profile of intensive blood pressure control amongst nondiabetic patients: a post hoc analysis of a randomized clinical trial.

   日本語解説
   Obi Y, Kalantar-Zadeh K, Shintani A, Kovesdy CP, Hamano T.

   J Intern Med. 2018 Mar;283(3):314-327. doi: 10.1111/joim.12701. Epub 2017 Nov 19.

8. Tolvaptan promotes urinary excretion of sodium and urea: a retrospective cohort study.

   Minami S, Hamano T, Iwatani H, Mizui M, Kimura Y, Isaka Y.

   Clin Exp Nephrol. 2018 Jun;22(3):550-561. doi: 10.1007/s10157-017-1475-9. Epub 2017 Oct 20.

9. Association of Parameters of Mineral Bone Disorder with Mortality in Patients on Hemodialysis according to Level of Residual Kidney Function.

   Wang M, Obi Y, Streja E, Rhee CM, Lau WL, Chen J, Hao C, Hamano T, Kovesdy CP, Kalantar-Zadeh K.

   Clin J Am Soc Nephrol. 2017 Jul 7;12(7):1118-1127. doi: 10.2215/CJN.11931116. Epub 2017 May 9.
   

10. [The effect of oral calcimimetics on cardiovascular events.]

    Hamano T.

    Clin Calcium. 2017;27(4):529-535. doi: CliCa1704529535. Japanese.

2016年

1. An unusual case of acute kidney injury after colonoscopy.

   Hashimoto N, Matsui I, Namba T, Oka T, Mori D, Sakaguchi Y, Mizui M, Hamano T, Takabatake Y, Isaka Y.

   Kidney Int. 2016 Sep;90(3):711. doi: 10.1016/j.kint.2016.06.024. No abstract available.

2. Association between Density of Coronary Artery Calcification and Serum Magnesium Levels among Patients with Chronic Kidney Disease.

   日本語解説
   Sakaguchi Y, Hamano T, Nakano C, Obi Y, Matsui I, Kusunoki Y, Mori D, Oka T, Hashimoto N, Takabatake Y, Takahashi A, Kaimori JY, Moriyama T, Yamamoto R, Horio M, Sugimoto K, Yamamoto K, Rakugi H, Isaka Y.

   PLoS One. 2016 Sep 23;11(9):e0163673. doi: 10.1371/journal.pone.0163673.

3. Intravenous Vitamin B6 Increases Resistance to Erythropoiesis-Stimulating Agents in Hemodialysis Patients: A Randomized Controlled Trial.

   Obi Y, Mikami S, Hamano T, Obi Y, Tanaka H, Shimomura A, Rakugi H, Inoue T, Isaka Y.

   J Ren Nutr. 2016 Nov;26(6):380-390. doi: 10.1053/j.jrn.2016.06.004.

4. Clinical features of CKD-MBD in Japan: cohort studies and registry.

   Hamano T, Sakaguchi Y, Fujii N, Isaka Y.

   Clin Exp Nephrol. 2016 Dec 9. [Epub ahead of print] Review.

5. Vitamin D Receptor Activator Use and Cause-specific Death among dialysis Patients: a Nationwide Cohort Study using Coarsened Exact Matching.
   

   Obi Y, Hamano T, Wada A, Tsubakihara Y, the Committee of Renal Data Registry of the Japanese Society for Dialysis Therapy.

   Sci Rep. 2017 Jan 31;7:41170. doi: 10.1038/srep41170.
   

6. Neglected visual function impairment associated with cornea verticillata due to Fabry disease.
   

   Koh S, Hamano T, Sakai N, Maeda N, Nishida K
   

   Intern Med J. 2017 Aug;47(8):969-971. doi: 10.1111/imj.13501.

7. Peritoneal Dialysis Registry With 2013 Survey Report.

   Masakane I, Hasegawa T, Ogata S, Kimata N, Nakai S, Hanafusa N, Hamano T, Wakai K, Wada A, Nitta K.

   Ther Apher Dial. 2016 Dec;20(6):557-568.

2015年

1. Excess 25-hydroxyvitamin D3 exacerbates tubulointerstitial injury in mice by modulating macrophage phenotype.
   日本語解説
   

   Kusunoki Y, Matsui I, Hamano T, Shimomura A, Mori D, Yonemoto S, Takabatake Y, Tsubakihara Y, St-Arnaud R, Isaka Y, Rakugi H.

   Kidney Int. 2015 Nov;88(5):1013-29. doi: 10.1038/ki.2015.210. Epub 2015 Jul 15.
   

2. Pre- and/or Intra-Operative Prescription of Diuretics, but Not Renin-Angiotensin-System Inhibitors, Is Significantly Associated with Acute Kidney Injury after Non-Cardiac Surgery: A Retrospective Cohort Study.

   Tagawa M, Ogata A, Hamano T.

   PLoS One. 2015 Jul 6;10(7):e0132507. doi: 10.1371/journal.pone.0132507. eCollection 2015.

3. Thresholds of iron markers for iron deficiency erythropoiesis-finding of the Japanese nationwide dialysis registry.

   Hamano T, Fujii N, Hayashi T, Yamamoto H, Iseki K, Tsubakihara Y.

   Kidney Int Suppl (2011). 2015 Jun;5(1):23-32.

4. Magnesium modifies the association between serum phosphate and the risk of progression to end-stage kidney disease in patients with non-diabetic chronic kidney disease.
   日本語解説
   

   Sakaguchi Y, Iwatani H, Hamano T, Tomida K, Kawabata H, Kusunoki Y, Shimomura A, Matsui I, Hayashi T, Tsubakihara Y, Isaka Y, Rakugi H.

   Kidney Int. 2015 Oct;88(4):833-42. doi: 10.1038/ki.2015.165. Epub 2015 Jun 10.

5. Prevalence and prognostic implications of vitamin D deficiency in chronic kidney disease.

   Obi Y, Hamano T, Isaka Y.

   Dis Markers. 2015;2015:868961. doi: 10.1155/2015/868961. Epub 2015 Mar 26. Review.

6. Klotho upregulation by rapamycin protects against vascular disease in CKD.

   Hamano T.

   Kidney Int. 2015 Oct;88(4):660-2. doi: 10.1038/ki.2015.223.

7. Peritoneal Dialysis Registry With 2012 Survey Report.

   Hasegawa T, Nakai S, Moriishi M, Ito Y, Itami N, Masakane I, Hanafusa N, Taniguchi M, Hamano T, Shoji T, Yamagata K, Shinoda T, Kazama J, Watanabe Y, Shigematsu T, Marubayashi S, Morita O, Wada A, Hashimoto S, Suzuki K, Kimata N, Wakai K, Fujii N, Ogata S, Tsuchida K, Nishi H, Iseki K, Tsubakihara Y, Nakamoto H.

   Ther Apher Dial. 2015 Dec;19(6):529-39. doi: 10.1111/1744-9987.12382.

8. An Overview of Regular Dialysis Treatment in Japan (As of 31 December 2013).

   Masakane I, Nakai S, Ogata S, Kimata N, Hanafusa N, Hamano T, Wakai K, Wada A, Nitta K.

   Ther Apher Dial. 2015 Dec;19(6):540-74. doi: 10.1111/1744-9987.12378.

---

2014年

1. Mineral Metabolism Markers Are Associated with Myocardial Infarction and Hemorrhagic Stroke but Not Ischemic Stroke in Hemodialysis Patients: A Longitudinal Study.

   Tagawa M, Hamano T, Nishi H, Tsuchida K, Hanafusa N, Fukatsu A, Iseki K, Tsubakihara Y.

   PLoS One. 2014 Dec 10;9(12):e114678. doi: 10.1371/journal.pone.0114678. eCollection 2014.

2. Dietary L-lysine prevents arterial calcification in adenine-induced uremic rats.
   日本語解説
   

   Shimomura A, Matsui I, Hamano T, Ishimoto T, Katou Y, Takehana K, Inoue K, Kusunoki Y, Mori D, Nakano C, Obi Y, Fujii N, Takabatake Y, Nakano T, Tsubakihara Y, Isaka Y, Rakugi H.

   J Am Soc Nephrol. 2014 Sep;25(9):1954-65. doi: 10.1681/ASN.2013090967. Epub 2014 Mar 20.

3. The change history of the INDEPENDENT Study in the ClinicalTrials.gov database.

   Obi Y, Hamano T.

   Am J Kidney Dis. 2014 Jan;63(1):164. doi: 10.1053/j.ajkd.2013.08.022. Epub 2013 Oct 25. 

4. Vitamin D deficiency predicts decline in kidney allograft function: a prospective cohort study.
   日本語解説
   

   Obi Y, Hamano T, Ichimaru N, Tomida K, Matsui I, Fujii N, Okumi M, Kaimori JY, Yazawa K, Kokado Y, Nonomura N, Rakugi H, Takahara S, Isaka Y, Tsubakihara Y.

   J Clin Endocrinol Metab. 2014 Feb;99(2):527-35. doi: 10.1210/jc.2013-2421. Epub 2013 Nov 27.

5. Multidetector-row computed tomography is useful to evaluate the therapeutic effects of bisphosphonates in glucocorticoid-induced osteoporosis.
   日本語解説
   

   Inoue K, Hamano T, Nango N, Matsui I, Tomida K, Mikami S, Fujii N, Nakano C, Obi Y, Shimomura A, Kusunoki Y, Rakugi H, Isaka Y, Tsubakihara Y.

   J Bone Miner Metab. 2014 May;32(3):271-80. doi: 10.1007/s00774-013-0485-2. Epub 2013 Jul 6.

---

2013年

1. Fibroblast growth factor 23 and 25-hydroxyvitamin D levels are associated with estimated glomerular filtration rate decline.

   Hamano T, Nakano C, Obi Y, Fujii N, Matsui I, Tomida K, Mikami S, Inoue K, Shimomura A, Kusunoki Y, Rakugi H, Isaka Y, Tsubakihara Y.

   Kidney Int Suppl (2011). 2013 Dec;3(5):469-475.

2. Serum phosphate and calcium should be primarily and consistently controlled in prevalent hemodialysis patients.

   Taniguchi M, Fukagawa M, Fujii N, Hamano T, Shoji T, Yokoyama K, Nakai S, Shigematsu T, Iseki K, Tsubakihara Y; Committee of Renal Data Registry of the Japanese Society for Dialysis Therapy.

   Ther Apher Dial. 2013 Apr;17(2):221-8. doi: 10.1111/1744-9987.12030.

3. Retention of fetuin-A in renal tubular lumen protects the kidney from nephrocalcinosis in rats.
   日本語解説
   

   Matsui I, Hamano T, Mikami S, Inoue K, Shimomura A, Nagasawa Y, Michigami T, Ohnishi T, Fujii N, Nakano C, Kusunoki Y, Kitamura H, Iwatani H, Takabatake Y, Kaimori JY, Matsuba G, Okoshi K, Kimura-Suda H, Tsubakihara Y, Rakugi H, Isaka Y.

   Am J Physiol Renal Physiol. 2013 Mar 15;304(6):F751-60. doi: 10.1152/ajprenal.00329.2012. Epub 2013 Jan 23.

---

2012年

1. Maxacalcitol ameliorates tubulointerstitial fibrosis in obstructed kidneys by recruiting PPM1A/VDR complex to pSmad3.
   日本語解説
   

   Inoue K, Matsui I, Hamano T, Fujii N, Shimomura A, Nakano C, Kusunoki Y, Takabatake Y, Hirata M, Nishiyama A, Tsubakihara Y, Isaka Y, Rakugi H.

   Lab Invest. 2012 Dec;92(12):1686-97. doi: 10.1038/labinvest.2012.107. Epub 2012 Aug 27.

2. Orally active vitamin d for potential chemoprevention of posttransplant malignancy.

   Obi Y, Ichimaru N, Hamano T, Tomida K, Matsui I, Fujii N, Okumi M, Kaimori JY, Yazawa K, Kokado Y, Tsubakihara Y, Nonomura N, Rakugi H, Takahara S, Isaka Y.

   Cancer Prev Res (Phila). 2012 Oct;5(10):1229-35. doi: 10.1158/1940-6207.CAPR-12-0218. Epub 2012 Aug 27.

3. Dialysis vintage and parathyroid hormone level, not fibroblast growth factor-23, determines chronic-phase phosphate wasting after renal transplantation.

   Tomida K, Hamano T, Ichimaru N, Fujii N, Matsui I, Nonomura N, Tsubakihara Y, Rakugi H, Takahara S, Isaka Y.

   Bone. 2012 Oct;51(4):729-36. doi: 10.1016/j.bone.2012.06.027. Epub 2012 Jul 14.

4. Intact fibroblast growth factor 23 levels predict incident cardiovascular event before but not after the start of dialysis.
   日本語解説
   

   Nakano C, Hamano T, Fujii N, Obi Y, Matsui I, Tomida K, Mikami S, Inoue K, Shimomura A, Nagasawa Y, Okada N, Tsubakihara Y, Rakugi H, Isaka Y.

   Bone. 2012 Jun;50(6):1266-74. doi: 10.1016/j.bone.2012.02.634. Epub 2012 Mar 6.

5. Combined use of vitamin D status and FGF23 for risk stratification of renal outcome.
   日本語解説
   

   Nakano C, Hamano T, Fujii N, Matsui I, Tomida K, Mikami S, Inoue K, Obi Y, Okada N, Tsubakihara Y, Isaka Y, Rakugi H.

   Clin J Am Soc Nephrol. 2012 May;7(5):810-9. doi: 10.2215/CJN.08680811. Epub 2012 Feb 23.

---